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The Kolbe-Schmitt reaction is an organic reaction used to convert a phenol to a hydroxy benzoic acid using carbon dioxide gas, a base, and acid work-up. The Kolbe-Schmitt reaction has been a standard procedure for the preparation of the Kolbe-Schmitt reaction in the form of a general survey. Special emphasis. PDF | On Oct 2, , Zoran Markovic and others published Mechanism of the Kolbe—Schmitt Reaction. Structure of the Intermediate.

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D in and for his work on Salicylic acid he scgmitt his habilitation in Views Read Edit View history. From Wikipedia, the free encyclopedia. Salicylic acid topic Salicylic acid from Latin salix, willow tree is a lipophilic monohydroxybenzoic acid, a type of phenolic acid, and a beta hydroxy acid BHA.

They are also used as food additives. Salts and esters of carboxylic acids are called carboxylates. The Kolbe—Schmitt reaction proceeds via the nucleophile addition of a phenoxide, classically sodium phenoxide NaOCHto carbon dioxide to give the salicylate. References Gerald Booth Annalen der Chemie und Pharmacie.

Greenhouse gases Revolvy Brain revolvybrain. Carbon dioxide consists of a carbon atom covalently double bonded to two oxygen atoms.

Kolbe–Schmitt reaction

A reagent that delivers the formyl group is called a formylating agent. Reaciton anion, phenoxide, also known as phenolate, is the conjugate base of phenol.

Member feedback about Augustine of Hippo: It is prepared by carboxylation of 2-naphthol via the Kolbe—Schmitt reaction. The Kolbe—Schmitt reaction proceeds via the nucleophile addition of a phenoxide, classically sodium phenoxide NaOC 6 H 5to carbon dioxide to give the salicylate.


Schmitt is a German surname. In addition to serving as an important active metabolite of aspirin acetylsalicylic acidwhich acts in part as a prodrug to salicylic acid, it is probably best known for its use as a key ingredient in topical anti-acne products.

Use dmy dates from June He started studying mathematics, theology and chemistry, but later concentrated on chemistry.

Hydroxy acids Revolvy Brain revolvybrain. The methodology is also used in the industrial synthesis of 3-hydroxynaphthoic acid. Parabens are effective preservatives in many types of formulas. Nonsteroidal anti-inflammatory drug topic Nonsteroidal anti-inflammatory drugs NSAIDs are kolbee drug class that reduce pain, decrease fever, prevent blood clots and, in higher doses, decrease inflammation.

Ullmann’s Encyclopedia of Industrial Chemistry.

Kolbe-Schmitt reaction

In this reatcion, solid acids are used as catalyst to generate the incipient carbocation. Reaction mechanisms Revolvy Brain revolvybrain fatmax fatmax. Scientific phenomena named after people topic This is a list of scientific phenomena and concepts named after people eponymous phenomena. Aromatic formylation Formylation reactions are a form of electrophilic aromatic substitution and therefore work best when the aromatic starting materials are electron-rich.

Sodium phenoxide is an organic compound echmitt the formula NaOCH.

Illustrated Glossary of Organic Chemistry – Kolbe-Schmitt reaction (Kolbe process)

Some of the most important electrophilic aromatic substitutions are aromatic nitration, aromatic halogenation, aromatic sulfonation, and acylation and alkylating Friedel—Crafts reaction. Member feedback about Mark Foley scandal: Salicylate decarboxylase EC 4. It is used as a precursor to many other organic compounds, such as aryl ethers.


The regiochemistry of the carboxylation in this case is sensitive to temperature. The methodology is also used in the industrial synthesis of 3-hydroxynaphthoic acid. The compound is also found in Ganoderma lucidum, a medicinal mushroom raction the longest record of use. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone.

Many other electrophilic reactions of benzene are conducted, although on much smaller scale, they are valuable routes to key intermediates. He was the bishop of Hippo Regius in north Africa and is viewed as one of the most important Church Fathers in Western Christianity for his writings rexction the Patristic Period. By using potassium hydroxide4-hydroxybenzoic acid is accessible, an kolbs precursor for the versatile paraben class of biocides used e.

Retrieved from ” https: Monomers Revolvy Brain revolvybrain. Because carbon dioxide is soluble in water, it occurs naturally in groundwater, rivers and lakes, ice caps, glaciers and seawater. For its part, the Catholic Church tea He worked at the University of Kassel and later the commercial school in Nuremberg.